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-altered mCRPC. This isn't due to an imbalance in germline mutations but may be relevant to far more monoallelic mutations and/or concurrent TP53
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mutations (two of 5) which were evaluable for zygosity status were biallelic alterations, Whilst eighty five% of evaluable BRCA2
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Más de la mitad de la economía mundial, valorada en 58 billones de dólares, depende en alto o moderado grado de la naturaleza y sus servicios, por lo que la gestión de los riesgos relacionados con la naturaleza es una cuestión materials para cualquier empresa e institución financiera.
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mutations. Furthermore, the tissue varieties used for tumor mutation analyses diversified (occasionally involving archival Most important tumor tissue, often involving metastatic biopsies, and sometimes relying on ctDNA samples). Although the use of archival tissues is unlikely to significantly alter the prevalence of BRCA1
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We have found that the medical exercise of PARP inhibitors is diminished in mCRPC patients with germline or somatic BRCA1
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Hacer más visibles las dependencias en la toma de decisiones empresariales y de inversión es un primer paso important para comprender mejor los riesgos relacionados con la naturaleza. Del mismo modo, identificar los factores de impacto que provocan cambios en el money purely natural puede ayudar a las organizaciones a valorar la pérdida resultante. Por ejemplo, ciertos enfoques de la producción agrícola podrían impulsar la conversión de tierras que contribuye a la disminución de las poblaciones de especies, incluidos los polinizadores, con la consiguiente reducción de la productividad y el rendimiento de los cultivos.